Resveratrol impaired the morphological transition of Candida albicans under various hyphae-inducing conditions.

Resveratrol Impaired the Morphological Transition of Candida albicans Under Various Hyphae-inducing Conditions Running title: Resveratrol inhibition of C. albicans dimorphism

Gymnemic Acids Inhibit Hyphal Growth and Virulence in Candida albicans

Candida albicans is an opportunistic and polymorphic fungal pathogen that causes mucosal, disseminated and invasive infections in humans. Transition from the yeast form to the hyphal form is one of the key virulence factors in C. albicans contributing to macrophage evasion, tissue invasion and biofilm formation. Nontoxic small molecules that inhibit C. albicans yeast-to-hypha conversion and hyp...

The role of microfilaments and microtubules during pH-regulated morphological transition in Candida albicans.

Yeast cells of Candida albicans produced germ tubes in a salt-glucose medium containing 4% calf serum at pH 7 and 37 degrees C. Hyphal growth continued for 24 h and the filaments did not revert to yeast cells. When cells were grown at pH 4, reversion to yeast growth was observed, despite the presence of serum. The elongation of hyphae was inhibited within 30 min. The distribution of microtubule...

Polarized hyphal growth in Candida albicans requires the Wiskott-Aldrich Syndrome protein homolog Wal1p.

The yeast-to-hypha transition is a key feature in the cell biology of the dimorphic human fungal pathogen Candida albicans. Reorganization of the actin cytoskeleton is required for this dimorphic switch in Candida. We show that C. albicans WAL1 mutants with both copies of the Wiskott-Aldrich syndrome protein (WASP) homolog deleted do not form hyphae under all inducing conditions tested. Growth ...

Glabridin triggers over-expression of apoptosis inducing factor (AIF) gene in Candida albicans

Background and Purpose: Candida albicans is a prevalent human fungal pathogen that can cause a wide spectrum of diseases, from superficial mucosal infections to systemic disorders, in patients with impaired immunity. Glabridin is a pyranoisoflavan originally extracted from root extract of Glycyrrhiza glabra. Glabridin can also mediate apoptosis in yeast cells by changing the mitochondrial membr...